Millennium Research Institute

Principal Investigator
Laboratory Co-Laboratory Director, Millennium Laboratories

Our Co-Laboratory Director is the world renowned Toxicologist, Amadeo J. Pesce, Ph.D., DABCC. Dr. Pesce is the author/editor of 32 textbooks and monographs and more than 200 peer-reviewed articles on chemistry, toxicology, and drug testing procedures. As an esteemed researcher, Dr. Pesce also serves as the Principal Investigator of the Millennium Research Institute (MRI). Many of his published papers are concerned with the clinical and toxicological aspects of therapeutic drug monitoring. A frequent speaker at national and international conferences, Dr. Pesce is recognized as a pioneer and leading light in the scientific community. He is Board Certified by the American Board of Clinical Chemistry and is an Adjunct Professor, Department of Pathology and Laboratory Medicine, in the University of California-San Diego School of Medicine.

Outstanding Toxicology Resource for Our Customers

Our customers reap the substantial benefits of working with a clinical laboratory director with thirty-five years of hands-on experience in laboratory sciences. Dr. Pesce’s vast knowledge and comprehensive experience is a valuable toxicology resource that is directly available to Millennium Laboratories customers. Our customers can contact Dr. Pesce by phone with questions on the clinical interpretation of patient test results. He is available for a full 12 hour window every business day.

Leading Pain Management from Forensics Model to Therapeutic Care

Utilizing the latest advantages of LC-MS/MS technology and applying it to problems facing chronic pain physicians, Dr. Pesce’s contributions to toxicology are ongoing as he develops future programs in urine drug screen testing, advanced educational opportunities for pharmacology students within our laboratory, and new research to be published soon.

Dr. Pesce has been instrumental in establishing the guidelines for 21st Century Therapeutic Drug Monitoring. He was a member of the team that wrote the latest guidelines establishing the international standards for normal values (also called reference intervals) found in naturally-occurring substances in the body (i.e. glucose, sodium, thyroid hormone, etc.) These were improved ways to determine reference interval guidelines that physicians use to interpret lab results. The current research Dr. Pesce is conducting expands the limits for drug and metabolite quantification – showing higher upper limit ranges as well as much lower limits than the majority of laboratories offer. Among Dr. Pesce’s numerous and notable accomplishments, he, along with Dr. Ann Warner and Catherine Hammett-Stabler, organized the publication, “Standards of Laboratory Practice: Therapeutic Drug Monitoring,” (NACB, 1998) sponsored by the National Academy of Clinical Biochemistry. This collaborative effort set the guidelines for therapeutic drug monitoring.

On July 1, 2009, the patent, “Method for Identifying Pain Medication Drug Abuse or Unusual Metabolism,” was filed by Dr. Pesce and the Millennium Laboratories clinical team. This patent will employ mathematical models to broaden the ability to detect drug abuse or misuse or unusual patient metabolisms, providing physicians with more exacting tools for the management of their chronic pain patients. A faculty member at the University of California, San Diego (UCSD) Department of Pathology and Laboratory Medicine, Dr. Pesce is a preceptor for Pharm. D students performing research on pain medication metabolism in conjunction with the resources of Millennium Laboratories and the faculty of the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences.

Acclaimed, Definitive Textbook on Clinical Chemistry

Dr. Amadeo Pesce co-edited, “Clinical Chemistry: Theory, Analysis, Correlation,” (Mosby, 1984, 1989, 1996, 2002, 2009) with Dr. Lawrence Kaplan. Now in its fifth edition, the acclaimed textbook is a complete clinical chemistry course and professional reference, providing detailed information on the principles of clinical chemistry for the monitoring and detection of disease. Dr. Pesce and Dr. Kaplan collaborated on three editions of the accompanying Workbook and Study Guide (Pesce Kaplan, 1985, 1989, 2003). They also produced the successful reference text, “Methods in Clinical Chemistry,” (Mosby, 1987; Pesce, Kaplan, 2009).

Leadership Impact in Toxicology, Clinical Chemistry and TDM

Dr. Pesce’s impressive background includes past President of the American Board of Clinical Chemistry, Professor Emeritus at University of Cincinnati and Adjunct Professor in the Department of Pathology and Laboratory Medicine at the University of California, San Diego. He holds Clinical Laboratory Director’s Licenses in California and Nevada and a Certificate of Qualification from the State of New York.

Dr. Pesce received a BS degree in Biology from the Massachusetts Institute of Technology (MIT), Ph.D. in Biochemistry from Brandeis University, and a National Institutes of Health (NIH) postdoctoral fellowship to study Biophysics at the University of Illinois at Urbana.

For more information, contact us online or toll free at 877-451-3534.

List of published textbooks and monographs:

1. Pesce A.J, Rosen CG, Pasby T. Fluorescence Spectroscopy: An Introduction for Biology and Medicine. New York, New York: Marcel Dekker; 1971
2. Brewer JM, Pesce AJ, Ashworth RB, eds. Experimental Techniques in Biochemistry. Englewood Cliffs, New Jersey:  Prentice-Hall; 1974.
3. Engvall E, Pesce AJ, eds. Quantitative Enzyme Immunoassay. Scandinavian J. of Immunology, 1978; (supplement 7).
4. Natelson S, Pesce AJ and Dietz A, eds. Clinical Immunochemistry. Washington, D.C.: American Association for Clinical Chemistry; 1978.
5. Pesce AJ, First MR. Proteinuria – An Integrated Review. New York, New York: Marcel Dekker; 1979.
6. Kaplan LA, Pesce AJ, eds. Non-Isotopic Alternatives to Radioimmuno-assay: Principles and Applications. New York, New York: Marcel Dekker; 1981.
7. Kaplan LA, Pesce AJ, eds. Clinical Chemistry: Theory, Methods and Practice. St. Louis, MO: C.V. Mosby Co.; 1984:1500.
8. Kaplan LA, Pesce AJ. Workbook and Guide for Clinical Chemistry: Theory, Methods and Practice: Cincinnati, OH: Pesce and Kaplan, Publishers; 1985.
9. Pesce AJ, Kaplan LA., eds. Methods in Clinical Chemistry. St. Louis, MO: C.V. Mosby Co.; 1987; 1400.
10. Kaplan L.A, Pesce AJ, eds. 2nd Edition. Clinical Chemistry Theory, Analysis and Correlation. St. Louis, MO: C.V. Mosby Co.; 1989; 1,100.
11. Kaplan LA., Pesce A.J, Knepp E. 2nd Edition. Clinical Chemistry Theory, Analysis and Correlation Workbook and Study Guide. Cincinnati, OH: Pesce and Kaplan, Publishers; 1989.
12. Pesce J, Pesce AJ. The lead paint primer: Questions and answers on lead paint poisoning. Melrose, MA: Star Industries; 1991.
13. Warner AM, Hohnadel D, Pesce AJ, et al, eds. Professional Practice in Toxicology: A Review. Washington, D.C. American Association for Clinical Chemistry: 1992; 598.
14. Pesce A.J, Warner AM, Hohnadel DC, et al. Professional Practice in Toxicology: A Review: Case Studies. Washington, D.C.: American Association for Clinical Chemistry Press; 1992; 115.
15. Avrameas S, Nakane PK., Papmichail M, Pesce A.J, guest eds. 25 Years of Immunoenzymatic Techniques. International Congress, J. Immunological Methods. 1992; 150 (1-2) (special edition):1-220.
16. Warner AM, Hohnadel D, Pesce AJ, et al, eds. Professional Practice in Toxicology: A Review. Washington, D.C. American Association for Clinical Chemistry: 1993; 742.
17. Wolf L, ed in chief, Pesce AJ, Warner AM, et al, eds. Professional Practice in Toxicology: A Review Case Studies. Washington, D.C.: American Association for Clinical Chemistry Press: 1993; 169.
18. Warner AM, Hohnadel D, Pesce AJ, et al, eds. Professional Practice in Toxicology: A Review. Washington, D.C.: American Association for Clinical Chemistry; 1994; 742.
19. Wolf L, ed in chief, Pesce AJ, Warner AM, et al. Professional Practice in Toxicology: A Review: Case Studies. Washington, D.C.: American Association for Clinical Chemistry Press; 1994; 169.
20. Pesce J and Pesce AJ. 2nd edition The lead paint primer: Questions and answers on lead paint poisoning. Melrose, MA: Star Industries; 1995.
21. Kaplan LA., Pesce AJ, eds. 3rd edition. Clinical Chemistry Theory, Analysis and Correlation. St. Louis, MO: C.V. Mosby Co.; 1996; 1,100.
22. Pesce A.J., Kaplan, LA. Clinical Chemistry: A Scientific and Managerial Infobase. Version 1.6. Cincinnati,  Ohio: Pesce- Kaplan Publishers, Inc.; 1996.
23. Pesce A.J, Kaplan, LA. Laboratory Medicine: A Scientific and Managerial Infobase. Version 2.1. Cincinnati, Ohio: Pesce-Kaplan Publishers, Inc.; 1997.
24. Pesce A.J, Kaplan LA. Laboratory Medicine: A Scientific and Managerial Infobase. Version 3.1. Cincinnati, Ohio: Pesce-Kaplan Publishers, Inc; 1998.
25. Pesce AJ, Kaplan LA. Laboratory Medicine: A Scientific and Managerial Infobase. Version 4.1. Cincinnati, Ohio: Pesce- Kaplan Publishers, Inc.; 1999.
26. Pesce A.J, Kaplan LA. Laboratory Medicine: Management Forms. Version 4.1. Cincinnati, Ohio: Pesce-Kaplan Publishers, Inc.; 1999.
27. Pesce AJ, Kaplan, LA. Laboratory Medicine: Urinalysis. Version 4.1. Cincinnati, Ohio: Pesce-Kaplan Publishers, Inc.; 1999.
28. Pesce AJ, Kaplan, LA. Laboratory Medicine: Urinalysis. Version 5.1. Cincinnati, Ohio: Pesce-Kaplan Publishers, Inc.; 2002.
29. Kaplan LA., Pesce AJ, eds. 4th edition. Clinical Chemistry Theory, Analysis and Correlation. St. Louis, MO: C.V. Mosby Co.; 2003; 1,100 pages plus CD-ROM.
30. Pesce AJ. Samuel R. Natelson: Biography and Writings. Washington, D.C.: Prepared for the History Division of the American Association for Clinical Chemistry; 2004.
31. Horn PS, Pesce AJ. Reference Intervals: A Users Guide. Washington, D.C.: American Association for Clinical Chemistry Press; 2005; 123 pages plus CD-ROM.
32. Kaplan LA, Pesce AJ., eds. 5th edition. Clinical Chemistry Theory, Analysis and Correlation. New York, New York:  Elsevier; 2009; 1,100 pages plus 144 online chapters found at  www.evolve.elsevier.com